The Fraunhofer Institute for Translational Medicine and Pharmacology ITMP investigates and develops innovative methods for the early detection, diagnosis and treatment of diseases resulting from impaired immune system functions.

The ITMP Translational Neuroinflammation and Automated Microscopy TNM site in Göttingen has extensive expertise in the preclinical research of neurodegenerative diseases as well as the application and further development of high-resolution light microscopy for the in-depth characterization of new pharmacological agents. We want to discover new pathophysiological targets in chronically progressive brain diseases and make them therapeutically usable by means of innovative strategies.

One methodological focus is on the automation of innovative high-resolution and super-resolution microscopy techniques, with which we can visualize sub-cellular structures in high-throughput procedures. In combination with novel image analysis algorithms, we can thus test the influence of active substances on the nanostructure of (living) cells with high throughput.

Various preclinical animal and cell culture models for multiple sclerosis allow in-depth research into the efficacy of new pharmacological agents for targeted application in the central nervous system.

Through an Early Clinical Trial Unit (ECTU) in cooperation with the University Medical Center Göttingen, the site has the possibility to test thoroughly characterized drug candidates and therapeutic approaches in phase I clinical trials.
 

Technologies:

• Innovative super-resolution microscopy
• Automation of microscopy processes
• Innovative image evaluation algorithms
• iPSCs and organoids
• Preclinical cell culture and animal models
• Phase I Unit